Gender-specific difference of clinical and plaque characteristics in myocardial infarction with non-obstructive artery (MINOCA): insights from optical coherence tomography

Abstract Background To date, sparse data are available with regard to gender differences in coronary plaque morphology and composition as underlying mechanism of MINOCA. Purpose assess the culprit lesion between women men MINOCA using intravascular optical coherence tomography. Methods Totally, 7404 consecutives acute myocardial infarction patients who underwent emergency angiography 2016 2019 were screened. identified 292 (mean age: 72.6% male, 54.1% ST-segment elevation). Optical tomography was performed 190 (men, n=142). Results Women older (62.5±10.6 vs. 54.0±11.5, P<0.001) more over 55 years (75.3% 43.6%, P<0.001). Although frequently presented NSTEMI (56.8% 41.7%, P=0.025) prior artery disease (CAD) (33.3% 6.3%, P<0.001), they less likely smoker (27.2% 58.8%, There no significant difference incidence rupture, erosion calcified nodule women. However, have thin-cap fibroatheroma (TCFA) (39.6% 22.5%, P=0.025). Conclusion older, smoking compared men. Besides, TCFA observed Funding Acknowledgement Type funding sources: None. Clinical OCT profilesProportion clinical profiles